ISSN 1662-4009 (online)

ey0020.13-11 | Section | ESPEYB20

13.11. Etiology of the broad avoidant restrictive food intake disorder phenotype in Swedish twins aged 6 to 12 years

L Dinkler , ML Wronski , P Lichtenstein , S Lundstrom , H Larsson , N Micali , MJ Taylor , CM Bulik

In Brief: The authors analysed data from the nationwide Child and Adolescent Twin Study in Sweden (CATSS) to estimate the heritability of avoidant restrictive food intake disorder (ARFID) as defined by DSM-5 criteria. Of the 16 951 twin pairs born between 1992 and 2010, 682 (2.0%) children were identified to have ARFID. By modelling shared risk in monozygous compared to dizygous twin pairs, they estimated the heritability of ARFID as 79% (95%CI, 70–85).<...

ey0017.15-15 | (1) | ESPEYB17

15.15. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

A Ganna , KJH Verweij , MG Nivard , R Maier , R Wedow , AS Busch , A Abdellaoui , S Guo , JF Sathirapongsasuti , 23andMe Research Team , P Lichtenstein , S Lundstrom , N Langstrom , A Auton , KM Harris , GW Beecham , ER Martin , AR Sanders , JRB Perry , BM Neale , BP Zietsch

To read the full abstract: Science 2019;365:eaat7693.These authors performed a genome-wide association study on 493 001 participants of European-ancestry from the USA, UK, and Sweden to identify genes associated with sexual orientation. They found multiple loci implicated in same-sex sexual behavior indicating that, like other behavioral traits, non-heterosexual behavior is polygenic.As many as 4% to 10% of US individuals ...